The wild-type enzyme did not hydrolyze the substrate, and thus, the introduction of a single histidine residue transformed the wild-type enzyme into a turnover system for thiol-ester hydrolysis
Eric Topol, MDs Post Two new studies zero in on the anti-inflammatory effects of the GLP-1 family of drugs, independent of weight loss, highlighting the gut-brain axis (modulating TLR response) and the gut GIP impact by Daniel Drucker and colleagues This opens up the possibility of using GLP-1 drugs in the treatment of long COVID or in conditions like schizophrenia that use the TLR pathway to activate neuroinflammation
SGLT-2 inhibitors and GLP-1 receptor agonists for nephroprotection and cardioprotection in patients with diabetes mellitus and chronic kidney disease
The contraindications for semaglutide include a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), known hypersensitivity to semaglutide or any product components, and for Wegovy specifically, pregnancy
beta-Hydroxylation of trimethyllysine by an alpha-ketoglutarate-dependent mitochondrial dioxygenase
